Honestly, the only servants which I would consider unlocking anything over mana loading would be Herc and saber Gilles.
One is a solo monster whose dammage comes from cards rather than np and the additional performance on extra attack COULD arguably be better than mana loading, but I’m not completely convinced.
The other has a useless NP on all levels.
Mana loading, even if not leveled gives you a lot of comp flexibility, regardless of card type, with respect to supports and CEs. Even just getting to that first NP could be extremely useful to get things going. It is for sure best for gameplay efficiency.
It is still up to you though and the way you want to play.
To be clear, NO APPEND SKILL is necessary to beat any hard content in the game, this includes 90+ nodes. So you shouldn’t stress to much on your choice.
Edit: regarding lvl 100+, I wi pick one servant and commit to him, and only because I love this servant and use him/her all the time. Unless you plan to farm 400+ boxes per lotto, it will take you a loong time to lvl 120 any one servant. (Reminder going from lvl 100 to 120 requires the embers from 500+ boxes). So I would not recommend lvling up more than 1 servant to 120 at a time.